RAD-140 for Sale: Everything You Need to Know

RAD-140s Mechanism of Action in Muscle and Strength Enhancement

RAD-140 (Testolone) is a non-steroidal, selective androgen receptor modulator or SARM. It selectively binds to the androgen receptor (AR) with high affinity (Kd ~7 nM) in a very tissue-selective manner [1]. It works by mimicking the anabolic effects of testosterone by activating androgen receptors in muscle and bone without seeming to affect the prostate or skin tissue [1]. Therefore, minimising and potentially eliminating some of the adverse effects common with testosterone.

Key Actions:

• AR Agonism in Muscle Tissue: RAD-140 promotes muscle hypertrophy by binding to ARs in skeletal muscle, initiating a conformational change that recruits coactivators and facilitates gene transcription involved in muscle growth [5].
• Increased Protein Synthesis: Thanks to its androgenic activation, RAD-140 boosts the activity of genes like Myogenin, MyoD and MyH. These genes all have main roles in muscle growth, so this helps tell the body’s muscle-building cells to grow and form new, stronger muscle tissue [6].
• Anabolic vs. Androgenic Selectivity: RAD-140 does not convert to DHT or estradiol, unlike testosterone, which helps minimise side effects in other areas like the prostate [1].

In preclinical trials RAD-140 increased lean body mass (LBM) and improved strength. For instance, one study reported increases in leg press strength and stair-climbing power (i.e., increased measures of performance) following short-term administration of SARMs in healthy men, showing RAD-140's functional capacity in muscle performance enhancement​ [7].

MAPK/ERK Signaling and Neuroprotection

RAD-140 appears to help protect brain cells by triggering certain fast-acting cell signals. Especially a pathway called MAPK (mitogen-activated protein kinase) which plays a key role in keeping brain cells healthy and resistant to damage.

In Brain and Neural Tissue:

• Activation of ERK1/2: One study showed RAD-140 activated the MAPK/ERK pathway in neuronal cells. A critical signaling domino effect that regulates cell survival and cell stress response [4].
• Protection from Apoptotic Insults: By promoting ERK1/2 phosphorylation RAD140 reduces cell death in hippocampal neurons that are exposed to oxidative stress or β-amyloid. This suggests a protective role in neurodegenerative contexts [4].
• Mechanism: This neuroprotection occurs via ligand-dependent AR modulation—RAD140 binds the AR, which in turn triggers kinase signaling independent of nuclear gene transcription. This rapid, extranuclear mechanism is a hallmark of non-genomic androgen action [4].

One rodent study showed that RAD140 protected hippocampal neurons from cell death while avoiding androgenic stimulation in peripheral tissues like the prostate, reinforcing its selectivity and dual anabolic/neuroprotective roles [4]​.

What is RAD-140 Best For?

Below are some of the documented benefits of RAD-140:

Promotes Bone Density and Muscular Strength

By activating receptors in bone tissue that support bone strength and structure it may promote bone mineralization. Preclinical studies show that RAD-140 might help:

• Increase bone mineral density, potentially reducing the risk of fractures and osteoporosis [8].
• Support musculoskeletal integrity, so it’s a great research candidate for conditions such as age related bone weakness [8].

Stimulating Muscle Growth and Hypertrophy

By stimulating muscle-building pathways and encouraging the formation of new muscle fibers it appears to stimulate lean muscle mass gains and muscle strength. According to research, RAD-140:

• Promotes muscle hypertrophy - by enhancing myogenic differentiation (upregulating key factors like MyoD and myogenin) [6]
• Encourages the formation of new muscle fibers (myotubes), therefore facilitating regeneration and growth [6].
• Prevents muscle wasting, which is critical in cachexia, sarcopenia and long-term muscle degeneration illnesses [3].
• Avoids conversion to estrogen or DHT which minimises side effects [1].

Enhancing Endurance and Performance

By increasing red blood cell production and in turn improving oxygen delivery to muscles, RAD-140 research shows potential for improving physical performance, aerobic capacity, endurance and overall exercise performance.  This is thanks to its stimulatory effects on erythropoietin production [3].

Improving Recovery and Reducing Inflammation

By reducing inflammation and helping muscle cells repair and regenerate after periods of stress, RAD-140 might help in speeding up muscle recovery. Research shows RAD-140 may promote:

• Downregulation of pro-inflammatory cytokines in muscle tissue [9].
• Upregulation of satellite cell activity, helping the repair and regeneration of damaged fibers [9].
• Reduced oxidative stress through MAPK/ERK signaling activation, which further supports tissue repair and neuroprotection [4].

Neuroprotective Potential

RAD-140 has shown protective effects on neural tissue, particularly in hippocampal neurons. According to research it does this by activating non-genomic androgen receptor signaling and may help protect against apoptotic insults and oxidative damage [4].

Its neuroprotective potential makes it a positive candidate for research into Alzheimer’s and other neurodegenerative disorders. Early studies suggest that RAD-140 may reduce neuronal cell death and support cognitive function [4].

Can Athletes Add RAD-140 to Their Supplement Regimen?

RAD-140 (Testolone) has not been approved for human consumption.

Despite this, many athletes and bodybuilders are keen to see how effective it could be as a safer alternative to testosterone for improving exercise performance.

In research, RAD-140 has been shown and is currently being explored to:

• Increase lean muscle mass, strength and performance [3,7]
• Support bone health and red blood cell production [3,8]

• Improve workout intensity and volume [3]
• Speed up recovery windows between training sessions [9]

Researchers have stated that their subjects had increases in strength, along with improved stamina, focus and endurance [3,7]. These positive results along with the absence of significant estrogen conversion, make RAD-140 very promising for performance-based research and suggest that in theory, it could be a safer alternative to testosterone if ever approved for clinical use  [1,3].

*It should be noted that RAD-140 is included on the banned substances list of the World Anti-Doping Agency and will result in a positive test for performance-enhancing substances in tests given as part of a doping control program [10]. It is also important to understand that RAD-140, while it shows promise in helping with conditions like muscle-wasting disease, is not approved for use in humans and therefore competitive sports.

While RAD-140 is recognized for its selective anabolic and tissue-recruiting action, its safety for human use is largely unknown. The compound has not been reviewed by the FDA, and it has only been tested in a few preclinical and early-phase clinical trials. Current research and case reports provide a better understanding of RAD-140's possible short-term and long-term side effects.

Hormonal imbalances caused by testosterone suppression:

A few studies and some case reports indicated a reduction of total and free testosterone levels as well as luteinizing hormone and follicle-stimulating hormone [2,11]. Hormone imbalances after a long cycle may cause fatigue, mood swings, or a decreased libido if proper PCT protocols are not followed.

Liver enzyme elevation (rare but more serious):

People often consider RAD-140 to be safe for the liver, but some studies have shown it to increase the levels of ALT and AST (two of the main indicators of liver stress) [11]. In rare instances RAD-140 may be linked to some severe forms of liver injury, including inflammation and damage to the liver's main functional cells, the hepatocytes. A 2020 case study for RAD-140 reported injuries to the liver. The subject showed symptoms of a bad hepatitis (jaundice, lots of fatigue, and discomfort in the abdomen) [12]. In animal studies, liver stress was observed at doses greater than 10 mg/kg [12].

RAD-140 is not approved for human consumption and should be used only for research purposes.

Do I Need a PCT & Other Supplements?

Yes. After a RAD-140 cycle, post-cycle therapy (PCT) is essential to restore hormonal balance, support testosterone levels and protect against potential side effects like fatigue and estrogen rebound.

Without a PCT, this may lead to symptoms like hormonal crashes causing mood swings, fatigue, or low libido, the loss of muscle gains or potential estrogen-related side effects.

At SARMs Australia, we offer two science-backed, natural PCTs made specifically to support post-cycle recovery from SARMs like RAD-140:

PCT 2.0 - a powerful herbal-based formula that promotes natural testosterone production, making it ideal for restoring hormonal balance after RAD-140 cycles. Tribulus is widely studied for its testosterone-boosting potential, while Ginseng (a known adaptogen) helps regulate stress, support energy levels, and improve mood.

Benefits:

• Stimulates natural testosterone levels
• Assists in maintaining lean muscle mass
• Supports mood, energy, and endocrine function
• Non-hormonal and safe for post-cycle therapy

T-Recovery - a complete recovery support formula designed to enhance testosterone production, improve performance, and protect against muscle wasting. With multiple natural anabolic compounds, it helps regulate estrogen levels and improves post-cycle metabolic recovery.

Key benefits:

• Boosts testosterone levels naturally
• Enhances recovery and exercise performance
• Aids in maintaining muscle growth and strength
• Regulates hormones without synthetic additives
• Can be taken both on or off cycle to promote healthy test levels

The legality of RAD-140 depends on where you are located and the intended use of the product. In most countries RAD-140 is legal to buy and possess but only for research purposes. It is important to check your local laws before purchasing RAD-140. It has not been approved by the FDA for human consumption or use as a dietary supplement.

Because RAD-140 is not regulated like traditional supplements, buying from a trusted supplier is critical. Poor-quality products can contain impurities, underdosed ingredients or even banned substances.

SARMs Australia is committed to providing premium-grade RAD-140, with strict quality controls and free express delivery across the country. Every order is backed by a 100% money-back guarantee, giving you peace of mind from a trusted supplier.

If you want to buy RAD-140 online, make sure you are ordering from a trusted supplier that prioritises purity, offers money back guarantees and has secure payment options. Be sure to keep an eye out for companies that sting you with shipping fees once you’ve made it to checkout.

Unfortunately there’s a bunch of questionable companies offering underdosed/contaminated compounds. They often have lower priced products and unsafe looking websites. While they may look good at first, do your due diligence to check whether they’re legit and whether they dilute their compounds with food-grade oils (like grapeseed oil) or harsher dissolving agents.

Why Choose SARMs Australia

SARMs Australia is the #1 supplier of research-grade SARMs. We sell the highest quality SARMs across the globe (backed by our 100% money back guarantee), have excellent customer service and include FREE express shipping to give you the best experience.

Here’s why researchers across Australia trust us when they buy RAD-140:

• 99.9% purity
• Premium quality assurance backed by a 100% money-back guarantee
• Free express shipping with guaranteed delivery (or we resend)
• Friendly and knowledgeable support team
• Transparent pricing: View both current price (when bought in bulk) and original price (when bought individually) clearly
• Flexible & Secure Payment Options (Card, Bank Transfer, Crypto)

We stand by our quality — and your satisfaction. If you're not happy with the product our team will make it right.

That's how we've built a reputation as the most reliable SARMs supplier in the region.

RAD-140 is intended for research purposes only. This means there is no recommended dosage and will depend on the study being performed.
SARMs Australia’s RAD 140 has a concentration of 10mg/mL.

Yes. Stacking SARMs has shown to produce more results and the decision of which SARMs to stack it with depends on the research being conducted. Research suggests the following:

• LGD-4033 (Ligandrol) – Theoretically shows great promise for enhancing muscle mass and strength [2,7]
• Ostarine (MK-2866) – May assist with muscle preservation and joint support [6]
• Ibutamoren (MK-677) – May improve growth hormone output, increase appetite and promote greater muscle-building [3]

RAD-140 is not for human consumption, is banned in professional sports and is classified under anabolic agents on the WADA Prohibited List [10].

It is detectable in performance enhancing drug (PED) urine tests and can lead to penalties, suspensions or disqualification in any tested competition.

Research involving RAD-140 suggests subjects may experience:

• Increases in lean muscle mass [3,7]
• Improved strength gains and performance [3,7]
• Enhanced muscle recovery post-workout [9]

Reduced body fat with increased muscle tone [3]

RAD-140 is primarily being studied for its potent anabolic effects on muscle tissue such as:

• Muscle building and muscle wasting prevention [3,7]
• Natural testosterone support and hormonal balance [2,11]
• Improving bone density [8]
• Neuroprotection through MAPK pathway activation [4]

It has also been studied in the context of fat loss, improved body composition and age-related muscle degeneration [3].

RAD-140 is well known for promoting muscle growth in clinical settings. Its strong affinity for androgen receptors in muscle tissue stimulates protein synthesis, improves muscle fiber recovery, and leads to measurable muscle gains with minimal fat gain [1,6,7].

In many studies, RAD-140 outperforms older compounds in both lean muscle mass retention and strength performance, making it ideal for research focused on anabolic response [3,7].